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Phenotypic alteration of neutrophils in the blood of HIV seropositive patients.

ABSTRACT: We have recently identified a novel population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells of HIV seropositive patients. LDGs have a similar morphology to normal density granulocytes (NDGs), but are phenotypically different. Here we measured the expression levels of different phenotypic markers of granulocytes in the blood of HIV seropositive patients at different stages of HIV infection to determine whether the phenotype of NDGs and LDGs are affected by disease severity. Our results reveal that the phenotype of NDGs, but not that of LDGs, varies according to the severity of the disease.

SUBMITTER: Cloke T

PROVIDER: S-EPMC3767740 | biostudies-other | 2013

REPOSITORIES: biostudies-other

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Phenotypic alteration of neutrophils in the blood of HIV seropositive patients.

Cloke Tom T Munder Markus M Bergin Philip P Herath Shanthi S Modolell Manuel M Taylor Graham G Müller Ingrid I Kropf Pascale P

PloS one 20130909 9

We have recently identified a novel population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells of HIV seropositive patients. LDGs have a similar morphology to normal density granulocytes (NDGs), but are phenotypically different. Here we measured the expression levels of different phenotypic markers of granulocytes in the blood of HIV seropositive patients at different stages of HIV infection to determine whether the phenotype of NDGs and LDGs are affected by di ...[more]

PMID: 24039734

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