Ontology highlight
ABSTRACT:
SUBMITTER: Cao W
PROVIDER: S-EPMC3772379 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Scientific reports 20130101
Enzyme inhibition due to the reversible binding of reaction products is common and underlies the origins of negative feedback inhibition in many metabolic and signaling pathways. Product inhibition generates non-linearity in steady-state time courses of enzyme activity, which limits the utility of well-established enzymology approaches developed under the assumption of irreversible product release. For more than a century, numerous attempts to find a mathematical solution for analysis of kinetic ...[more]