Ontology highlight
ABSTRACT:
SUBMITTER: Schellinger JG
PROVIDER: S-EPMC3773086 | biostudies-other | 2013 Aug
REPOSITORIES: biostudies-other
Schellinger Joan G JG Pahang Joshuel A JA Shi Julie J Pun Suzie H SH
ACS macro letters 20130801 8
Endosomal release peptides have been incorporated in synthetic gene delivery formulations to increase transfection efficiencies. In this work, cationic copolymers containing sHGP, a membrane-lytic peptide derived from HIV gp41, were synthesized and evaluated. Diblock, with sHGP displayed on one block, and statistical, with sHGP randomly displayed, copolymers were prepared via RAFT polymerization. While the statistical copolymer existed as unimers in solution, amphiphilic diblock copolymers self- ...[more]