Ontology highlight
ABSTRACT:
SUBMITTER: Nemazanyy I
PROVIDER: S-EPMC3779449 | biostudies-other | 2013 Jun
REPOSITORIES: biostudies-other
Nemazanyy Ivan I Blaauw Bert B Paolini Cecilia C Caillaud Catherine C Protasi Feliciano F Mueller Amelie A Proikas-Cezanne Tassula T Russell Ryan C RC Guan Kun-Liang KL Nishino Ichizo I Sandri Marco M Pende Mario M Panasyuk Ganna G
EMBO molecular medicine 20130430 6
The complex of Vacuolar Protein Sorting 34 and 15 (Vps34 and Vps15) has Class III phosphatidylinositol 3-kinase activity and putative roles in nutrient sensing, mammalian Target Of Rapamycin (mTOR) activation by amino acids, cell growth, vesicular trafficking and autophagy. Contrary to expectations, here we show that Vps15-deficient mouse tissues are competent for LC3-positive autophagosome formation and maintain mTOR activation. However, an impaired lysosomal function in mutant cells is traced ...[more]