Ontology highlight
ABSTRACT:
SUBMITTER: Corkins ME
PROVIDER: S-EPMC3780850 | biostudies-other | 2013 Sep
REPOSITORIES: biostudies-other
Corkins Mark E ME May Margot M Ehrensberger Kate M KM Hu Ya-Mei YM Liu Yi-Hsuan YH Bloor Sean D SD Jenkins Blair B Runge Kurt W KW Bird Amanda J AJ
Proceedings of the National Academy of Sciences of the United States of America 20130903 38
In Schizosaccharomyces pombe, alcohol dehydrogenase 1 (Adh1) is an abundant zinc-requiring enzyme that catalyses the conversion of acetaldehyde to ethanol during fermentation. In a zinc-replete cell, adh1 is highly expressed. However, in zinc-limited cells, adh1 gene expression is repressed, and cells induce the expression of an alternative alcohol dehydrogenase encoded by the adh4 gene. In our studies examining this zinc-dependent switch in alcohol dehydrogenase gene expression, we isolated an ...[more]