Ontology highlight
ABSTRACT:
SUBMITTER: Duran RV
PROVIDER: S-EPMC3787797 | biostudies-other | 2013 Sep
REPOSITORIES: biostudies-other
Durán R V RV MacKenzie E D ED Boulahbel H H Frezza C C Heiserich L L Tardito S S Bussolati O O Rocha S S Hall M N MN Gottlieb E E
Oncogene 20121022 38
Hypoxia-inducible factor (HIF) prolyl hydroxylases (PHDs) are α-ketoglutarate (αKG)-dependent dioxygenases that function as cellular oxygen sensors. However, PHD activity also depends on factors other than oxygen, especially αKG, a key metabolic compound closely linked to amino-acid metabolism. We examined the connection between amino-acid availability and PHD activity. We found that amino-acid starvation leads to αKG depletion and to PHD inactivation but not to HIF stabilization. Furthermore, p ...[more]