CYP2A6 genotype and smoking behavior in current smokers screened for lung cancer.
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ABSTRACT:
SUBMITTER: Styn MA
PROVIDER: S-EPMC3788637 | biostudies-other | 2013 May
REPOSITORIES: biostudies-other
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CYP2A6 genotype and smoking behavior in current smokers screened for lung cancer.
Styn Mindi A MA Nukui Tomoko T Romkes Marjorie M Perkins Kenneth A KA Land Stephanie R SR Weissfeld Joel L JL
Substance use & misuse 20130325 7
Functional CYP2A6 genetic variation partially determines nicotine metabolism. In 2005, we examined functional CYP2A6 variants associated with reduced metabolism (CYP2A6*2, CYP2A6*9, CYP2A6*4), smoking history, and change in smoking in 878 adult smokers undergoing lung cancer screening in an urban setting. At one year, 216 quit smoking for more than 30 days while 662 continued smoking. Compared to subjects who smoked 30 cigarettes per day at baseline, the odds of a reduced metabolism genotype was ...[more]
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