Validation and clinical utility of prostate cancer biomarkers.
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ABSTRACT:
SUBMITTER: Scher HI
PROVIDER: S-EPMC3790270 | biostudies-other | 2013 Apr
REPOSITORIES: biostudies-other
Publications
Validation and clinical utility of prostate cancer biomarkers.
Scher Howard I HI Morris Michael J MJ Larson Steven S Heller Glenn G
Nature reviews. Clinical oncology 20130305 4
To improve future drug development and patient management for patients with castration-resistant prostate cancer (CRPC), surrogate biomarkers that are linked to relevant outcomes are urgently needed. A biomarker must be measurable, reproducible, linked to relevant clinical outcomes, and demonstrate clinical utility. This area is rapidly evolving, with recent trials in patients with CRPC incorporating the detection of circulating tumour cells (CTCs), imaging, and patient-reported outcome biomarke ...[more]
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