Ontology highlight
ABSTRACT:
SUBMITTER: Lum LG
PROVIDER: S-EPMC3792709 | biostudies-other | 2011 Dec
REPOSITORIES: biostudies-other
Lum Lawrence G LG Thakur Archana A
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20111201 6
Bispecific antibodies (BiAbs) offer a unique opportunity to redirect immune effector cells to kill cancer cells. BiAbs combine the benefits of different binding specificities of two monoclonal antibodies (mAbs) into a single construct. This unique feature of BiAbs enables approaches that are not possible with single mAbs. Advances in antibody engineering and antigen profiling of malignant cells have led to the development of a number of BiAb formats and their combinations for redirecting effecto ...[more]