Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC3799489 | biostudies-other | 2013 Sep
REPOSITORIES: biostudies-other
Zhang Yuqing Y Yang Jingxuan J Cui Xiaobo X Chen Yong Y Zhu Vivian F VF Hagan John P JP Wang Huamin H Yu Xianjun X Hodges Sally E SE Fang Jing J Chiao Paul J PJ Logsdon Craig D CD Fisher William E WE Brunicardi F Charles FC Chen Changyi C Yao Qizhi Q Fernandez-Zapico Martin E ME Li Min M
EMBO molecular medicine 20130716 9
Changes in the intracellular levels of the essential micronutrient zinc have been implicated in multiple diseases including pancreatic cancer; however, the molecular mechanism is poorly understood. Here, we report a novel mechanism where increased zinc mediated by the zinc importer ZIP4 transcriptionally induces miR-373 in pancreatic cancer to promote tumour growth. Reporter, expression and chromatin immunoprecipitation assays demonstrate that ZIP4 activates the zinc-dependent transcription fact ...[more]