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Epigenetics components of aging in the central nervous system.

ABSTRACT: This review highlights recent discoveries that have shaped the emerging viewpoints in the field of epigenetic influences in the central nervous system (CNS), focusing on the following questions: (i) How is the CNS shaped during development when precursor cells transition into morphologically and molecularly distinct cell types, and is this event driven by epigenetic alterations?; ii) How do epigenetic pathways control CNS function?; (iii) What happens to "epigenetic memory" during aging processes, and do these alterations cause CNS dysfunction?; (iv) Can one restore normal CNS function by manipulating the epigenome using pharmacologic agents, and will this ameliorate aging-related neurodegeneration? These and other still unanswered questions remain critical to understanding the impact of multifaceted epigenetic machinery on the age-related dysfunction of CNS.

SUBMITTER: Zhao YQ

PROVIDER: S-EPMC3805869 | biostudies-other | 2013 Oct

REPOSITORIES: biostudies-other

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Epigenetics components of aging in the central nervous system.

Zhao Yue-Qiang YQ Jordan I King IK Lunyak Victoria V VV

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20131001 4

This review highlights recent discoveries that have shaped the emerging viewpoints in the field of epigenetic influences in the central nervous system (CNS), focusing on the following questions: (i) How is the CNS shaped during development when precursor cells transition into morphologically and molecularly distinct cell types, and is this event driven by epigenetic alterations?; ii) How do epigenetic pathways control CNS function?; (iii) What happens to "epigenetic memory" during aging processe ...[more]

PMID: 24132650

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