Ontology highlight
ABSTRACT:
SUBMITTER: Jin HS
PROVIDER: S-EPMC3809788 | biostudies-other | 2013 Nov
REPOSITORIES: biostudies-other
Jin Hyung-seung HS Park Yoon Y Elly Chris C Liu Yun-Cai YC
The Journal of clinical investigation 20131025 11
Regulatory T (Treg) cells maintain immune homeostasis by limiting autoimmune and inflammatory responses. Treg differentiation, maintenance, and function are controlled by the transcription factor Foxp3. However, the exact molecular mechanisms underlying Treg cell regulation remain elusive. Here, we show that Treg cell-specific ablation of the E3 ubiquitin ligase Itch in mice caused massive multiorgan lymphocyte infiltration and skin lesions, chronic T cell activation, and the development of seve ...[more]