Ontology highlight
ABSTRACT:
SUBMITTER: Katayama S
PROVIDER: S-EPMC3810855 | biostudies-other | 2013 Nov
REPOSITORIES: biostudies-other
Katayama Shintaro S Töhönen Virpi V Linnarsson Sten S Kere Juha J
Bioinformatics (Oxford, England) 20130831 22
<h4>Motivation</h4>Recent transcriptome studies have revealed that total transcript numbers vary by cell type and condition; therefore, the statistical assumptions for single-cell transcriptome studies must be revisited. SAMstrt is an extension code for SAMseq, which is a statistical method for differential expression, to enable spike-in normalization and statistical testing based on the estimated absolute number of transcripts per cell for single-cell RNA-seq methods.<h4>Availability and implem ...[more]