Ontology highlight
ABSTRACT:
SUBMITTER: Li HQ
PROVIDER: S-EPMC3811894 | biostudies-other | 2013 Nov
REPOSITORIES: biostudies-other
Molecular and cellular biology 20130903 21
Brain disturbances, like injuries or aberrant protein deposits, evoke nucleotide release or leakage from cells, leading to microglial chemotaxis and ingestion. Recent studies have identified P2Y12 purinergic receptors as triggers for microglial chemotaxis and P2Y6 receptors as mediators for phagocytosis. However, pinocytosis, known as the internalization of fluid-phase materials, has received much less attention. We found that ATP efficiently triggered pinocytosis in microglia. Pharmacological a ...[more]