Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation.
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ABSTRACT:
SUBMITTER: Hall KT
PROVIDER: S-EPMC38135 | biostudies-other | 1996 Oct
REPOSITORIES: biostudies-other
Publications
Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation.
Hall K T KT Boumsell L L Schultze J L JL Boussiotis V A VA Dorfman D M DM Cardoso A A AA Bensussan A A Nadler L M LM Freeman G J GJ
Proceedings of the National Academy of Sciences of the United States of America 19961001 21
Herein we describe the molecular characterization of the human leukocyte activation antigen CD100 and identify it as the first semaphorin, to our knowledge, in the immune system. Semaphorins have recently been described as neuronal chemorepellants that direct pioneering neurons during nervous system development. In this study we demonstrate that CD100 induces B cells to aggregate and improves their viability in vitro. We show that CD100 modifies CD40-CD40L B-cell signaling by augmenting B-cell a ...[more]
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