Optical imaging to map blood-brain barrier leakage.
Ontology highlight
ABSTRACT:
SUBMITTER: Jaffer H
PROVIDER: S-EPMC3814906 | biostudies-other | 2013 Nov
REPOSITORIES: biostudies-other
Publications
Optical imaging to map blood-brain barrier leakage.
Jaffer Hayder H Adjei Isaac M IM Labhasetwar Vinod V
Scientific reports 20131101
Vascular leakage in the brain is a major complication associated with brain injuries and certain pathological conditions due to disruption of the blood-brain barrier (BBB). We have developed an optical imaging method, based on excitation and emission spectra of Evans Blue dye, that is >1000-fold more sensitive than conventional ultraviolet spectrophotometry. We used a rat thromboembolic stroke model to validate the usefulness of our method for vascular leakage. Optical imaging data show that vas ...[more]
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