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Oxidative stress and response in relation to coronary artery disease in type 1 diabetes.

ABSTRACT: Although oxidative stress (OxS) is thought to contribute to atherosclerosis and coronary artery disease (CAD), little is known about the variability in an individual's ability to respond to OxS. Therefore, we assessed potential indices of response to OxS and evaluated whether they modify the association between OxS and CAD.We evaluated plasma ?- and ?-tocopherol per unit cholesterol (potential response markers); urinary 15-isoprostane F2t per milligram creatinine (isoprostane [IsoP], a potential stress marker); and the ?-tocopherol-to-IsoP ratio (as a measure of response to stress), measured three times during 20 years of follow-up, in relation to CAD incidence in a cohort with childhood-onset type 1 diabetes (n = 658; mean age at baseline, 28 years; duration of diabetes, 19 years). Participants with three samples (blood and either 24-h or overnight urine) available before the onset of CAD or the end of follow-up (n = 356) were selected for study.In multivariable mixed models, ?-tocopherol over time was inversely associated with CAD (? = -0.27; P = 0.02), whereas a direct association was observed for IsoP (? = 0.0008; P = 0.06). Moreover, the ?-tocopherol-to-IsoP ratio was strongly and inversely related to CAD incidence (? = -0.72; P = 0.003), whereas in a separate model including ?-tocopherol and IsoP, both biomarkers maintained statistical significance. No association was observed for ?-tocopherol (? = -0.22; P = 0.54).These data suggest that a greater potential capability (?-tocopherol) to respond to OxS (urinary IsoP) relates to CAD incidence.

SUBMITTER: Costacou T

PROVIDER: S-EPMC3816903 | biostudies-other | 2013 Nov

REPOSITORIES: biostudies-other

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Oxidative stress and response in relation to coronary artery disease in type 1 diabetes.

Costacou Tina T Evans Rhobert W RW Schafer Gerald L GL Orchard Trevor J TJ

Diabetes care 20130806 11

<h4>Objective</h4>Although oxidative stress (OxS) is thought to contribute to atherosclerosis and coronary artery disease (CAD), little is known about the variability in an individual's ability to respond to OxS. Therefore, we assessed potential indices of response to OxS and evaluated whether they modify the association between OxS and CAD.<h4>Research design and methods</h4>We evaluated plasma α- and γ-tocopherol per unit cholesterol (potential response markers); urinary 15-isoprostane F2t per ...[more]

PMID: 23920084

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Project description:IntroductionAdipokines, expressed by adipose tissue (AT), have been associated with metabolic disturbances and coronary artery disease (CAD). The impact of exercise training on the AT in patients suffering from both diabetes and CAD is unknown. To gain knowledge on changes in ATs' inflammatory profile in such a population, we investigated the effects of long-term exercise on selected adipokines and their associations with physical performance and glucometabolic variables. Adiponectin was selected based on its anti-atherogenic and anti-diabetic properties and visfatin and tumour necrosis factor (TNF) for their association with atherosclerosis and metabolic disorders. Not many studies have focused on the effects of long-term exercise training on adipokines in patients with concomitant T2DM and CAD.MethodsPatients with type 2 diabetes and CAD (n = 137), 41-81 years, 17.2% females, were randomized in a 1:1 manner to an exercise group, who underwent 1 year of 150 min weekly combined strength and endurance exercise, or a control group. AT from the gluteal region and blood samples were obtained at baseline and after 12 months, along with a physical performance test, assessed by the VO2 peak. Circulating protein levels were measured by ELISA. RNA was extracted from AT and expression levels were relatively quantified by PCR.ResultsAfter 1 year, no significant difference in the change in the investigated markers between the intervention group and the control group was observed. Changes in circulating adiponectin and VO2 peak correlated in the total population (r = 0.256, p = 0.008). At baseline, circulating adiponectin and TNF correlated inversely with insulin and with C-peptide and VO2peak, respectively (p < 0.001, all).ConclusionIn this population with concomitant diabetes and CAD, ATs' inflammatory profile remained unchanged apparently after 1 year of exercise intervention. Changes in the VO2peak were nevertheless, related to changes in circulating adiponectin levels.Trial registrationhttp://www.clinicaltrials.gov NCT01232608.

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Oxidative stress and response in relation to coronary artery disease in type 1 diabetes.

Publications

Oxidative stress and response in relation to coronary artery disease in type 1 diabetes.

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