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MeCP2: making sense of missense in Rett syndrome.


ABSTRACT: Fine scale genomic regulation is critical for maintaining genomic integrity and is often disrupted in neurodevelopmental disorders. An intriguing new study reveals the intricate biochemical complexity of de novo post-translational modifications of MeCP2, including activity-dependent protein-protein interactions that 'bridge' the nuclear receptor co-repressor (NCoR) complex to chromatin and lead to alterations in gene expression that characterize Rett syndrome.

SUBMITTER: Banerjee A 

PROVIDER: S-EPMC3817541 | biostudies-other | 2013 Nov

REPOSITORIES: biostudies-other

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