Ontology highlight
ABSTRACT:
SUBMITTER: van Veen HW
PROVIDER: S-EPMC38212 | biostudies-other | 1996 Oct
REPOSITORIES: biostudies-other
van Veen H W HW Venema K K Bolhuis H H Oussenko I I Kok J J Poolman B B Driessen A J AJ Konings W N WN
Proceedings of the National Academy of Sciences of the United States of America 19961001 20
Resistance of Lactococcus lactis to cytotoxic compounds shares features with the multidrug resistance phenotype of mammalian tumor cells. Here, we report the gene cloning and functional characterization in Escherichia coli of LmrA, a lactococcal structural and functional homolog of the human multidrug resistance P-glycoprotein MDR1. LmrA is a 590-aa polypeptide that has a putative topology of six alpha-helical transmembrane segments in the N-terminal hydrophobic domain, followed by a hydrophilic ...[more]