Ontology highlight
ABSTRACT:
SUBMITTER: Colantonio JR
PROVIDER: S-EPMC3821763 | biostudies-other | 2009 Jan
REPOSITORIES: biostudies-other
Colantonio Jessica R JR Vermot Julien J Wu David D Langenbacher Adam D AD Fraser Scott S Chen Jau-Nian JN Hill Kent L KL
Nature 20081130 7226
In teleosts, proper balance and hearing depend on mechanical sensors in the inner ear. These sensors include actin-based microvilli and microtubule-based cilia that extend from the surface of sensory hair cells and attach to biomineralized 'ear stones' (or otoliths). Otolith number, size and placement are under strict developmental control, but the mechanisms that ensure otolith assembly atop specific cells of the sensory epithelium are unclear. Here we demonstrate that cilia motility is require ...[more]