Ontology highlight
ABSTRACT:
SUBMITTER: Zampieri BL
PROVIDER: S-EPMC3826801 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Disease markers 20120101 2
Studies have shown that the maternal risk for Down syndrome (DS) may be modulated by alterations in folate metabolism. The aim of this study was to evaluate the influence of 12 genetic polymorphisms involved in folate metabolism on maternal risk for DS. In addition, we evaluated the impact of these polymorphisms on serum folate and plasma methylmalonic acid (MMA, an indicator of vitamin B<formula>_{12}</formula> status) concentrations. The polymorphisms transcobalamin II (TCN2) c.776C>G, betaine ...[more]