Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population.
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ABSTRACT:
SUBMITTER: Meng W
PROVIDER: S-EPMC3827790 | biostudies-other | 2008
REPOSITORIES: biostudies-other
Publications
Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population.
Meng Weihua W Hughes Anne E AE Patterson Chris C CC Belton Christine C Kee Frank F McKeown Pascal P PP
Disease markers 20080101 2
Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males <or=55 yr, females <or=60 yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10 ...[more]
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