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Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population.


ABSTRACT: Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males

SUBMITTER: Meng W 

PROVIDER: S-EPMC3827790 | biostudies-other | 2008

REPOSITORIES: biostudies-other

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Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population.

Meng Weihua W   Hughes Anne E AE   Patterson Chris C CC   Belton Christine C   Kee Frank F   McKeown Pascal P PP  

Disease markers 20080101 2


Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males <or=55 yr, females <or=60 yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10  ...[more]

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