Ontology highlight
ABSTRACT:
SUBMITTER: van Solingen C
PROVIDER: S-EPMC3828868 | biostudies-other | 2009 Aug
REPOSITORIES: biostudies-other
van Solingen Coen C Seghers Leonard L Bijkerk Roel R Duijs Jacques M G J JM Roeten Marko K MK van Oeveren-Rietdijk Annemarie M AM Baelde Hans J HJ Monge Matthieu M Vos Joost B JB de Boer Hetty C HC Quax Paul H A PH Rabelink Ton J TJ van Zonneveld Anton Jan AJ
Journal of cellular and molecular medicine 20090801 8A
MicroRNAs are negative regulators of gene expression that play a key role in cell-type specific differentiation and modulation of cell function and have been proposed to be involved in neovascularization. Previously, using an extensive cloning and sequencing approach, we identified miR-126 to be specifically and highly expressed in human endothelial cells (EC). Here, we demonstrate EC-specific expression of miR-126 in capillaries and the larger vessels in vivo. We therefore explored the potentia ...[more]