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Dynamics of dendritic spines in the mouse auditory cortex during memory formation and memory recall.


ABSTRACT: Long-lasting changes in synaptic connections induced by relevant experiences are believed to represent the physical correlate of memories. Here, we combined chronic in vivo two-photon imaging of dendritic spines with auditory-cued classical conditioning to test if the formation of a fear memory is associated with structural changes of synapses in the mouse auditory cortex. We find that paired conditioning and unpaired conditioning induce a transient increase in spine formation or spine elimination, respectively. A fraction of spines formed during paired conditioning persists and leaves a long-lasting trace in the network. Memory recall triggered by the reexposure of mice to the sound cue did not lead to changes in spine dynamics. Our findings provide a synaptic mechanism for plasticity in sound responses of auditory cortex neurons induced by auditory-cued fear conditioning; they also show that retrieval of an auditory fear memory does not lead to a recapitulation of structural plasticity in the auditory cortex as observed during initial memory consolidation.

SUBMITTER: Moczulska KE 

PROVIDER: S-EPMC3831433 | biostudies-other | 2013 Nov

REPOSITORIES: biostudies-other

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Dynamics of dendritic spines in the mouse auditory cortex during memory formation and memory recall.

Moczulska Kaja Ewa KE   Tinter-Thiede Juliane J   Peter Manuel M   Ushakova Lyubov L   Wernle Tanja T   Bathellier Brice B   Rumpel Simon S  

Proceedings of the National Academy of Sciences of the United States of America 20131022 45


Long-lasting changes in synaptic connections induced by relevant experiences are believed to represent the physical correlate of memories. Here, we combined chronic in vivo two-photon imaging of dendritic spines with auditory-cued classical conditioning to test if the formation of a fear memory is associated with structural changes of synapses in the mouse auditory cortex. We find that paired conditioning and unpaired conditioning induce a transient increase in spine formation or spine eliminati  ...[more]

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