Ontology highlight
ABSTRACT:
SUBMITTER: Moczulska KE
PROVIDER: S-EPMC3831433 | biostudies-other | 2013 Nov
REPOSITORIES: biostudies-other
Moczulska Kaja Ewa KE Tinter-Thiede Juliane J Peter Manuel M Ushakova Lyubov L Wernle Tanja T Bathellier Brice B Rumpel Simon S
Proceedings of the National Academy of Sciences of the United States of America 20131022 45
Long-lasting changes in synaptic connections induced by relevant experiences are believed to represent the physical correlate of memories. Here, we combined chronic in vivo two-photon imaging of dendritic spines with auditory-cued classical conditioning to test if the formation of a fear memory is associated with structural changes of synapses in the mouse auditory cortex. We find that paired conditioning and unpaired conditioning induce a transient increase in spine formation or spine eliminati ...[more]