Ontology highlight
ABSTRACT:
SUBMITTER: Lee RG
PROVIDER: S-EPMC3838598 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Lee Richard G RG Crosby Jeff J Baker Brenda F BF Graham Mark J MJ Crooke Rosanne M RM
Journal of cardiovascular translational research 20130716 6
Antisense oligonucleotides and small interfering RNAs, which suppress the translation of specific mRNA target proteins, are emerging as important therapeutic modalities for the treatment of cardiovascular disease. Over the last 25 years, the advances in all aspects of antisense technology, as well as a detailed understanding of the mechanism of action of antisense drugs, have enabled their use as therapeutic agents. These advancements culminated in the FDA approval of the first chronically admin ...[more]