Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi D
PROVIDER: S-EPMC3840063 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Takahashi Daisuke D Kim Yunjeong Y Lovell Scott S Prakash Om O Groutas William C WC Chang Kyeong-Ok KO
Virus research 20130917 2
Noroviruses have a single-stranded, positive sense 7-8kb RNA genome, which encodes a polyprotein precursor processed by a virus-encoded 3C-like cysteine protease (3CLpro) to generate mature non-structural proteins. Because processing of the polyprotein is essential for virus replication, norovirus 3CLpro has been targeted for the discovery of anti-norovirus small molecule therapeutics. Thus, we performed functional, structural and inhibition studies of norovirus 3CLpro with fluorescence resonanc ...[more]