P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation.
Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura F
PROVIDER: S-EPMC38408 | biostudies-other | 1996 Sep
REPOSITORIES: biostudies-other
Publications
P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation.
Nakamura F F Strittmatter S M SM
Proceedings of the National Academy of Sciences of the United States of America 19960901 19
Somatic sensation requires the conversion of physical stimuli into the depolarization of distal nerve endings. A single cRNA derived from sensory neurons renders Xenopus laevis oocytes mechanosensitive and is found to encode a P2Y1 purinergic receptor. P2Y1 mRNA is concentrated in large-fiber dorsal root ganglion neurons. In contrast, P2X3 mRNA is localized to small-fiber sensory neurons and produces less mechanosensitivity in oocytes. The frequency of touch-induced action potentials from frog s ...[more]
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