Ontology highlight
ABSTRACT:
SUBMITTER: Johnson SL
PROVIDER: S-EPMC3843824 | biostudies-other | 2013 Nov
REPOSITORIES: biostudies-other
Johnson Stuart L SL Wedemeyer Carolina C Vetter Douglas E DE Adachi Roberto R Holley Matthew C MC Elgoyhen Ana Belén AB Marcotti Walter W
Open biology 20131101 11
Spontaneous electrical activity generated by developing sensory cells and neurons is crucial for the maturation of neural circuits. The full maturation of mammalian auditory inner hair cells (IHCs) depends on patterns of spontaneous action potentials during a 'critical period' of development. The intrinsic spiking activity of IHCs can be modulated by inhibitory input from cholinergic efferent fibres descending from the brainstem, which transiently innervate immature IHCs. However, it remains unk ...[more]