Ontology highlight
ABSTRACT:
SUBMITTER: Sinues B
PROVIDER: S-EPMC3850616 | biostudies-other | 2008
REPOSITORIES: biostudies-other
Sinués Blanca B Vicente Jorge J Fanlo Ana A Mayayo-Sinués Esteban E González-Andrade Fabricio F Sánchez-Q Dora D Martínez-Jarreta Begoña B
Disease markers 20080101 6
Polymorphisms in CYP3A genes, such as CYP3A5} and CYP3A4, as well as in the MDR1 gene, which encodes for P-glycoprotein, have been implicated as genetic markers in several disorders. Differences in the frequency distribution of the allelic variants CYP3A5 3, CYP3A4 1B, and MDR1 3435T have been demonstrated between distinct ethnic groups. In this study we examined the frequency of these allelic variants in 317 healthy Mestizo individuals from Ecuador and made comparisons with results reported in ...[more]