Unknown

Dataset Information

0

Post-traumatic tics and tetrabenazine treatment: a blinded video assessment.


ABSTRACT: Traumatic head injury is a very rare cause of secondary tic disorders. We add another case by describing, for the first time, the response to tetrabenazine in a blinded video assessment. Our patient had a severe traumatic head injury and subsequently developed tics refractory to various agents including neuroleptics. We assessed tetrabenazine treatment by virtue of patient's impression, the treating neurologist's non-blinded (Yale Global Tic Severity Scale) and a second neurologist's blinded assessment (modified Rush Video Scale). The Yale Global Tic Severity Score improved by 24% on 12.5 mg twice daily and 45% on 12.5 mg thrice daily. Subjective improvement was 50% and 70%, respectively. The modified Rush Video scores improved by 21% and 28.5%, respectively. Post-traumatic tourettism can respond to tetrabenazine. The magnitude of benefit though, may be overestimated with open-label observations, thus there is a need for studies examining objectively the effect of tetrabenazine in tic disorders.

SUBMITTER: Poulopoulos M 

PROVIDER: S-EPMC3863049 | biostudies-other | 2013

REPOSITORIES: biostudies-other

altmetric image

Publications

Post-traumatic tics and tetrabenazine treatment: a blinded video assessment.

Poulopoulos Markos M   Hajjar Mirna M  

BMJ case reports 20131205


Traumatic head injury is a very rare cause of secondary tic disorders. We add another case by describing, for the first time, the response to tetrabenazine in a blinded video assessment. Our patient had a severe traumatic head injury and subsequently developed tics refractory to various agents including neuroleptics. We assessed tetrabenazine treatment by virtue of patient's impression, the treating neurologist's non-blinded (Yale Global Tic Severity Scale) and a second neurologist's blinded ass  ...[more]

Similar Datasets

| S-EPMC7146962 | biostudies-literature
| S-EPMC7203017 | biostudies-literature
| S-EPMC8302199 | biostudies-literature
| S-EPMC6980474 | biostudies-literature
| S-EPMC8498196 | biostudies-literature
| S-EPMC5674654 | biostudies-literature
| S-EPMC7263835 | biostudies-literature
| S-EPMC4253016 | biostudies-literature
| S-EPMC6429626 | biostudies-literature
| S-EPMC4550904 | biostudies-other