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I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

ABSTRACT: Tumor necrosis factor (TNF) receptor-associated factor (TRAF) proteins associate with and transduce signals from TNF receptor 2, CD40, and presumably other members of the TNF receptor superfamily. TRAF2 is required for CD40- and TNF-mediated activation of the transcription factor NF-kappa B. Here we describe the isolation and characterization of a novel TRAF-interacting protein, I-TRAF, that binds to the conserved TRAF-C domain of the three known TRAFs. Overexpression of I-TRAF inhibits TRAF2-mediated NF-kappa B activation signaled by CD40 and both TNF receptors. Thus, I-TRAF appears as a natural regulator of TRAF function that may act by maintaining TRAFs in a latent state.

SUBMITTER: Rothe M

PROVIDER: S-EPMC38654 | biostudies-other | 1996 Aug

REPOSITORIES: biostudies-other

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I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

Rothe M M Xiong J J Shu H B HB Williamson K K Goddard A A Goeddel D V DV

Proceedings of the National Academy of Sciences of the United States of America 19960801 16

Tumor necrosis factor (TNF) receptor-associated factor (TRAF) proteins associate with and transduce signals from TNF receptor 2, CD40, and presumably other members of the TNF receptor superfamily. TRAF2 is required for CD40- and TNF-mediated activation of the transcription factor NF-kappa B. Here we describe the isolation and characterization of a novel TRAF-interacting protein, I-TRAF, that binds to the conserved TRAF-C domain of the three known TRAFs. Overexpression of I-TRAF inhibits TRAF2-me ...[more]

PMID: 8710854

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