Ontology highlight
ABSTRACT:
SUBMITTER: Karlin S
PROVIDER: S-EPMC38673 | biostudies-other | 1996 Aug
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19960801 16
We present new methods for identifying and analyzing statistically significant residue clusters that occur in three-dimensional (3D) protein structures. Residue clusters of different kinds occur in many contexts. They often feature the active site (e.g., in substrate binding), the interface between polypeptide units of protein complexes, regions of protein-protein and protein-nucleic acid interactions, or regions of metal ion coordination. The methods are illustrated with 3D clusters centering o ...[more]