Ontology highlight
ABSTRACT:
SUBMITTER: Sung PJ
PROVIDER: S-EPMC3870738 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Sung Pamela J PJ Tsai Frederick D FD Vais Horia H Court Helen H Yang Jun J Fehrenbacher Nicole N Foskett J Kevin JK Philips Mark R MR
Proceedings of the National Academy of Sciences of the United States of America 20131202 51
K-Ras4B is targeted to the plasma membrane by a farnesyl modification that operates in conjunction with a polybasic domain. We characterized a farnesyl-electrostatic switch whereby protein kinase C phosphorylates K-Ras4B on serine 181 in the polybasic region and thereby induces translocation from the plasma membrane to internal membranes that include the endoplasmic reticulum (ER) and outer mitochondrial membrane. This translocation is associated with cell death. Here we have explored the mechan ...[more]