Delivery of short hairpin RNA sequences by using a replication-competent avian retroviral vector.

ABSTRACT: While recent studies have demonstrated that retroviral vectors can be used to stably express short hairpin RNA (shRNA) to inhibit gene expression, these studies have utilized replication-defective retroviruses. We describe the creation of a replication-competent, Gateway-compatible retroviral vector capable of expressing shRNA that inhibits the expression of specific genes.

SUBMITTER: Bromberg-White JL 

PROVIDER: S-EPMC387706 | biostudies-other | 2004 May

REPOSITORIES: biostudies-other