Ontology highlight
ABSTRACT:
SUBMITTER: Islahudin F
PROVIDER: S-EPMC3885885 | biostudies-other | 2014 Jan
REPOSITORIES: biostudies-other
Scientific reports 20140109
The major antimalarial drug quinine perturbs uptake of the essential amino acid tryptophan, and patients with low plasma tryptophan are predisposed to adverse quinine reactions; symptoms of which are similar to indications of tryptophan depletion. As tryptophan is a precursor of the neurotransmitter serotonin (5-HT), here we test the hypothesis that quinine disrupts serotonin function. Quinine inhibited serotonin-induced proliferation of yeast as well as human (SHSY5Y) cells. One possible cause ...[more]