Ontology highlight
ABSTRACT:
SUBMITTER: Al-Sawaf O
PROVIDER: S-EPMC3887379 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Al-Sawaf Othman O Fragoulis Athanassios A Rosen Christian C Kan Yuet Wai YW Sönmez Tolga Taha TT Pufe Thomas T Wruck Christoph Jan CJ
Scientific reports 20140110
Skeletal muscle (SM) regeneration after injury is impaired by excessive inflammation. Particularly, the inflammatory cytokine tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a potent inducer of skeletal muscle wasting and fibrosis. In this study we investigated the role of Nrf2, a major regulator of oxidative stress defence, in SM ischemia/reperfusion (I/R) injury and TWEAK induced atrophy. We explored the time-dependent expression of TWEAK after I/R in SM of Nrf2-wildtype ...[more]