Ontology highlight
ABSTRACT:
SUBMITTER: Raina S
PROVIDER: S-EPMC3889232 | biostudies-other | 2014 Jan
REPOSITORIES: biostudies-other
Raina Sumeer S Chande Ajit G AG Baba Masanori M Mukhopadhyaya Robin R
Virusdisease 20130927 1
Human immunodeficiency virus regulatory protein Rev (regulator of viral expression) is translated from a monocistronic transcript produced early in the viral replication cycle. Rev binds to the cis-acting, highly structured viral RNA sequence Rev response element (RRE) and the Rev-RRE complex primarily controls nucleocytoplasmic transport of viral RNAs. Inhibition of Rev-RRE interaction therefore is an attractive target to block viral transport. We have developed a stable cell line carrying a le ...[more]