In vivo MRI cell tracking using perfluorocarbon probes and fluorine-19 detection.
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ABSTRACT: This article presents a brief review of preclinical in vivo cell-tracking methods and applications using perfluorocarbon (PFC) probes and fluorine-19 ((19) F) MRI detection. Detection of the (19) F signal offers high cell specificity and quantification ability in spin density-weighted MR images. We discuss the compositions of matter, methods and applications of PFC-based cell tracking using ex vivo and in situ PFC labeling in preclinical studies of inflammation and cellular therapeutics. We also address the potential applicability of (19) F cell tracking to clinical trials.
SUBMITTER: Ahrens ET
PROVIDER: S-EPMC3893103 | biostudies-other | 2013 Jul
REPOSITORIES: biostudies-other
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