Ontology highlight
ABSTRACT:
SUBMITTER: Meier ER
PROVIDER: S-EPMC3899685 | biostudies-other | 2012 May
REPOSITORIES: biostudies-other
Drugs 20120501 7
Early identification of infants with sickle cell disease (SCD) by newborn screening, now universal in all 50 states in the US, has improved survival, mainly by preventing overwhelming sepsis with the early use of prophylactic penicillin. Routine transcranial Doppler screening with the institution of chronic transfusion decreases the risk of stroke from 10% to 1% in paediatric SCD patients. Hydroxyurea decreases the number and frequency of painful crises, acute chest syndromes and number of blood ...[more]