Ontology highlight
ABSTRACT:
SUBMITTER: Kesavan G
PROVIDER: S-EPMC3899820 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Kesavan Gokul G Lieven Oliver O Mamidi Anant A Öhlin Zarah Löf ZL Johansson Jenny Kristina JK Li Wan-Chun WC Lommel Silvia S Greiner Thomas Uwe TU Semb Henrik H
Development (Cambridge, England) 20140201 3
Delamination plays a pivotal role during normal development and cancer. Previous work has demonstrated that delamination and epithelial cell movement within the plane of an epithelium are associated with a change in cellular phenotype. However, how this positional change is linked to differentiation remains unknown. Using the developing mouse pancreas as a model system, we show that β cell delamination and differentiation are two independent events, which are controlled by Cdc42/N-WASP signaling ...[more]