Ontology highlight
ABSTRACT:
SUBMITTER: Love NK
PROVIDER: S-EPMC3899821 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Love Nicola K NK Keshavan Nandaki N Lewis Rebecca R Harris William A WA Agathocleous Michalis M
Development (Cambridge, England) 20140201 3
In many growing tissues, slowly dividing stem cells give rise to rapidly proliferating progenitors that eventually exit the cell cycle and differentiate. Growth rates are limited by nutrient availability, but it is unclear which steps of the proliferation-differentiation programme are particularly sensitive to fuel supplies. We examined how nutrient deprivation (ND) affects stem and progenitor cells in the ciliary marginal zone (CMZ) of the amphibian retina, a well-characterised neurogenic niche ...[more]