Ontology highlight
ABSTRACT:
SUBMITTER: Battista D
PROVIDER: S-EPMC3902288 | biostudies-other | 2014 Jan
REPOSITORIES: biostudies-other
Battista Daniela D Ganat Yosif Y El Maarouf Abderrahman A Studer Lorenz L Rutishauser Urs U
Stem cells translational medicine 20131205 1
There has been considerable progress in obtaining engraftable embryonic stem (ES) cell-derived midbrain dopamine neurons for cell replacement therapy in models of Parkinson's disease; however, limited integration and striatal reinnervation of ES-derived grafts remain a major challenge for future clinical translation. In this paper, we show that enhanced expression of polysialic acid results in improved graft efficiency in correcting behavioral deficits in Parkinsonian mice. This result is accomp ...[more]