The telomere resolvase of the Lyme disease spirochete, Borrelia burgdorferi, promotes DNA single-strand annealing and strand exchange.
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ABSTRACT:
SUBMITTER: Mir T
PROVIDER: S-EPMC3905847 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Publications
The telomere resolvase of the Lyme disease spirochete, Borrelia burgdorferi, promotes DNA single-strand annealing and strand exchange.
Mir Taskia T Huang Shu Hui SH Kobryn Kerri K
Nucleic acids research 20130917 22
Spirochetes of the genus Borrelia include the tick-transmitted causative agents of Lyme disease and relapsing fever. They possess unusual genomes composed mainly of linear replicons terminated by closed DNA hairpin telomeres. Hairpin telomeres present an uninterrupted DNA chain to the replication machinery overcoming the 'end-replication problem' for the linear replicons. Hairpin telomeres are formed from inverted repeat replicated telomere junctions by the telomere resolvase, ResT. ResT uses a ...[more]
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