Ontology highlight
ABSTRACT:
SUBMITTER: Laresgoiti U
PROVIDER: S-EPMC3905855 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Laresgoiti Usua U Apraiz Aintzane A Olea Miguel M Mitxelena Jone J Osinalde Nerea N Rodriguez José A JA Fullaondo Asier A Zubiaga Ana M AM
Nucleic acids research 20130912 22
E2F2 is essential for the maintenance of T lymphocyte quiescence. To identify the full set of E2F2 target genes, and to gain further understanding of the role of E2F2 in transcriptional regulation, we have performed ChIP-chip analyses across the genome of lymph node-derived T lymphocytes. Here we show that during quiescence, E2F2 binds the promoters of a large number of genes involved in DNA metabolism and cell cycle regulation, concomitant with their transcriptional silencing. A comparison of C ...[more]