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Landmark trials affecting the surgical management of invasive breast cancer.


ABSTRACT: Significant progress has been made in the surgical management of breast cancer. Most women diagnosed with early stage invasive breast cancer can now be managed with breast-conserving therapy to include a segmental mastectomy followed by radiation. Axillary lymph nodes are routinely assessed by sentinel lymph node biopsy. Axillary lymph node dissection is reserved for patients with documented nodal metastasis; however, here too progress has been made because a population of low-risk patients has been identified in whom a complete dissection is not required even in the setting of a positive sentinel lymph node. This article details the landmark clinical trials that have guided the surgical management of breast cancer.

SUBMITTER: Black DM 

PROVIDER: S-EPMC3907110 | biostudies-other | 2013 Apr

REPOSITORIES: biostudies-other

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Landmark trials affecting the surgical management of invasive breast cancer.

Black Dalliah M DM   Mittendorf Elizabeth A EA  

The Surgical clinics of North America 20130129 2


Significant progress has been made in the surgical management of breast cancer. Most women diagnosed with early stage invasive breast cancer can now be managed with breast-conserving therapy to include a segmental mastectomy followed by radiation. Axillary lymph nodes are routinely assessed by sentinel lymph node biopsy. Axillary lymph node dissection is reserved for patients with documented nodal metastasis; however, here too progress has been made because a population of low-risk patients has  ...[more]

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