Ontology highlight
ABSTRACT:
SUBMITTER: Walker J
PROVIDER: S-EPMC3910799 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Antimicrobial agents and chemotherapy 20131014 1
GSK2336805 is an inhibitor of hepatitis C virus (HCV) with picomolar activity on the standard genotype 1a, 1b, and 2a subgenomic replicons and exhibits a modest serum shift. GSK2336805 was not active on 22 RNA and DNA viruses that were profiled. We have identified changes in the N-terminal region of NS5A that cause a decrease in the activity of GSK2336805. These mutations in the genotype 1b replicon showed modest shifts in compound activity (<13-fold), while mutations identified in the genotype ...[more]