Ontology highlight
ABSTRACT:
SUBMITTER: Robin NC
PROVIDER: S-EPMC3916759 | biostudies-other | 2014 Jan
REPOSITORIES: biostudies-other
Robin Nicholas C NC Agoston Zsuzsa Z Biechele Travis L TL James Richard G RG Berndt Jason D JD Moon Randall T RT
Stem cell reports 20131226 1
Statins improve recovery from traumatic brain injury and show promise in preventing Alzheimer disease. However, the mechanisms by which statins may be therapeutic for neurological conditions are not fully understood. In this study, we present the initial evidence that oral administration of simvastatin in mice enhances Wnt signaling in vivo. Concomitantly, simvastatin enhances neurogenesis in cultured adult neural progenitor cells as well as in the dentate gyrus of adult mice. Finally, we find t ...[more]