Ontology highlight
ABSTRACT:
SUBMITTER: Cullender TC
PROVIDER: S-EPMC3920589 | biostudies-other | 2013 Nov
REPOSITORIES: biostudies-other
Cullender Tyler C TC Chassaing Benoit B Janzon Anders A Kumar Krithika K Muller Catherine E CE Werner Jeffrey J JJ Angenent Largus T LT Bell M Elizabeth ME Hay Anthony G AG Peterson Daniel A DA Walter Jens J Vijay-Kumar Matam M Gewirtz Andrew T AT Ley Ruth E RE
Cell host & microbe 20131101 5
Gut mucosal barrier breakdown and inflammation have been associated with high levels of flagellin, the principal bacterial flagellar protein. Although several gut commensals can produce flagella, flagellin levels are low in the healthy gut, suggesting the existence of control mechanisms. We find that mice lacking the flagellin receptor Toll-like receptor 5 (TLR5) exhibit a profound loss of flagellin-specific immunoglobulins (Igs) despite higher total Ig levels in the gut. Ribotyping of IgA-coate ...[more]