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Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy.


ABSTRACT: Infection with Neospora caninum stimulates host cell-mediated immune responses, which may be responsible for placental damage leading to bovine abortion. The aim of this study was to compare immune responses in the bovine placenta, following experimental infection in different stages of pregnancy. Placentomes were examined by immunohistochemistry and inflammation in early gestation was generally moderate to severe, particularly in the placentas carrying non-viable foetuses, whereas it was milder in later stages, mainly characterised by the presence of CD3+, CD4+ and ?? T-cells. This distinctive cellular immune response may explain the milder clinical outcome observed when animals are infected in later gestation.

SUBMITTER: Canton GJ 

PROVIDER: S-EPMC3922085 | biostudies-other | 2014

REPOSITORIES: biostudies-other

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Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy.

Cantón Germán J GJ   Katzer Frank F   Maley Stephen W SW   Bartley Paul M PM   Benavides-Silván Julio J   Palarea-Albaladejo Javier J   Pang Yvonne Y   Smith Sionagh H SH   Rocchi Mara S MS   Buxton David D   Innes Elisabeth A EA   Chianini Francesca F  

Veterinary research 20140131


Infection with Neospora caninum stimulates host cell-mediated immune responses, which may be responsible for placental damage leading to bovine abortion. The aim of this study was to compare immune responses in the bovine placenta, following experimental infection in different stages of pregnancy. Placentomes were examined by immunohistochemistry and inflammation in early gestation was generally moderate to severe, particularly in the placentas carrying non-viable foetuses, whereas it was milder  ...[more]

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