Ontology highlight
ABSTRACT:
SUBMITTER: Kim I
PROVIDER: S-EPMC3926088 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20140124 6
Quantitative structure-based modeling of voltage activation of ion channels is very challenging. For example, it is very hard to reach converging results, by microscopic simulations while macroscopic treatments involve major uncertainties regarding key features. The current work overcomes some of the above challenges by using our recently developed coarse-grained (CG) model in simulating the activation of the Kv1.2 channel. The CG model has allowed us to explore problems that cannot be fully add ...[more]